Translating insights from neuropsychiatric genetics and genomics for precision psychiatry

The primary aim of precision medicine is to tailor healthcare more closely to the needs of individual patients. This requires progress in two areas: the development of more precise treatments and the ability to identify patients or groups of patients in the clinic for whom such treatments are likely to be the most effective. There is widespread optimism that advances in genomics will facilitate both of these endeavors. It can be argued that of all medical specialties psychiatry has most to gain in these respects, given its current reliance on syndromic diagnoses, the minimal foundation of existing mechanistic knowledge, and the substantial heritability of psychiatric phenotypes. Here, we review recent advances in psychiatric genomics and assess the likely impact of these findings on attempts to develop precision psychiatry. Emerging findings indicate a high degree of polygenicity and that genetic risk maps poorly onto the diagnostic categories used in the clinic. The highly polygenic and pleiotropic nature of psychiatric genetics will impact attempts to use genomic data for prediction and risk stratification, and also poses substantial challenges for conventional approaches to gaining biological insights from genetic findings. While there are many challenges to overcome, genomics is building an empirical platform upon which psychiatry can now progress towards better understanding of disease mechanisms, better treatments, and better ways of targeting treatments to the patients most likely to benefit, thus paving the way for precision psychiatry

Active Collaboration Learning Environments: The Class of Web 2.0

The maturity and increased integration of online collaboration, networking, and research tools offer Information Systems faculty opportunities to provide unique learning environments at multiple levels. A growing ensemble of Web 2.0 technologies provide the background to introduce and explore fundamental aspects of information system development, design, application, and use, while simultaneously providing a functional suite of tools which will aid students in other aspects of their university learning. A selection of these technologies and case studies of their classroom usage is discussed. In addition, an agenda for research in both pedagogy and in information systems phenomena is outlined

Beef Reproductive Technology Adoption- Impact of Production Risk and Capitals

Agriculture, Beef, Artificial insemination, Estrus synchronization, Social capital, Production risk, Technology adoption, Farm Management,

Tracing the water-energy-food nexus : description, theory and practice

The ‘nexus’ between water, energy and food (WEF) has gained increasing attention globally in research, business and policy spheres. We review the premise of recent initiatives framed around the nexus, examine the challenge of achieving the type of disciplinary boundary crossing promoted by the nexus agenda and consider how to operationalise what has to date been a largely paper exercise. The WEF nexus has been promoted through international meetings and calls for new research agendas. It is clear from the literature that many aims of nexus approaches pre-date the recent nexus agenda; these have encountered significant barriers to progress, including challenges to cross-disciplinary collaboration, complexity, political economy (often perceived to be under-represented in nexus research) and incompatibility of current institutional structures. Indeed, the ambitious aims of the nexus—the desire to capture multiple interdependencies across three major sectors, across disciplines and across scales—could become its downfall. However, greater recognition of interdependencies across state and non-state actors, more sophisticated modelling systems to assess and quantify WEF linkages and the sheer scale of WEF resource use globally, could create enough momentum to overcome historical barriers and establish nexus approaches as part of a wider repertoire of responses to global environmental change

Effects of diamagnetic levitation on bacterial growth in liquid

Diamagnetic levitation is a technique that uses a strong, spatially-varying magnetic field to levitate diamagnetic materials, such as water and biological cells. This technique has the potential to simulate aspects of weightlessness, on the Earth. In common with all ground-based techniques to simulate weightlessness, however, there are effects introduced by diamagnetic levitation that are not present in space. Since there have been few studies that systematically investigate these differences, diamagnetic levitation is not yet being fully exploited. For the first time, we critically assess the effect of diamagnetic levitation on a bacterial culture in liquid. We used a superconducting magnet to levitate growing bacterial cultures for up to 18 hours, in a series of experiments to determine the effect of diamagnetic levitation on all phases of the bacterial growth cycle. We find that diamagnetic levitation increases the rate of population growth in a liquid culture. The speed of sedimentation of the bacterial cells to the bottom of the container is considerably reduced. Further experiments and microarray gene analysis show that the growth enhancement is due to greater oxygen availability in the magnetically levitated sample. We demonstrate that the magnetic field that levitates the cells also induces convective stirring in the liquid, an effect not present in microgravity. We present a simple theoretical model, showing how the paramagnetic force on dissolved oxygen can cause the liquid to become unstable to convection when the consumption of oxygen by the bacteria generates an oxygen concentration gradient. We propose that this convection enhances oxygen availability by transporting oxygen around the sample. Since convection is absent in space, these results are of significant importance and timeliness to researchers considering using diamagnetic levitation to explore weightless effects on living organisms and a broad range of other topics in the physical and life sciences

Layer guided-acoustic plate mode biosensors for monitoring MHC-peptide interactions

The transduction signals from the immobilisation of a class I heavy chain, HLA-A2, on a layer guided acoustic plate mode device, followed by binding of beta(2)-microglobulin and subsequent selective binding of a target peptide are reported

Superoxide radicals can act synergistically with hypochlorite to induce damage to proteins

AbstractActivated phagocytes generate both superoxide radicals via a respiratory burst, and HOCl via the concurrent release of the haem enzyme myeloperoxidase. Amine and amide functions on proteins and carbohydrates are major targets for HOCl, generating chloramines (RNHCl) and chloramides (RC(O)NClR′), which can accumulate to high concentrations (>100 μM). Here we show that superoxide radicals catalyse the decomposition of chloramines and chloramides to reactive nitrogen-centred radicals, and increase the extent of protein fragmentation compared to that observed with either superoxide radicals or HOCl, alone. This synergistic action may be of significance at sites of inflammation, where both superoxide radicals and chloramines/chloramides are formed simultaneously